ISOLEUCINE AND VALINE METABOLISM IN ESCHERICHIA COLI V

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Isoleucine and valine metabolism in Escherichia coli. V. Antagonism between isoleucine and valine.

The influence of the relative concentrations of amino acids in culture media on the growth of microorganisms was first brought to the attention of microbiologists by Gladstone (1939). He observed that isoleucine, valine, or leucine added singly to a synthetic medium inhibited the growth of the anthrax bacillus whereas a mixture of the three stimulated growth. Although Gladstone was unable at th...

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Isoleucine and Valine Metabolism of Escherichia Coli

In the preceding publication (1) mention has been made of the syntrophism existing between the mutant strains llA16 and 2OA19 of Escherichia COG. These mutants, requiring isoleucine and isoleucine plus valine respectively, were able to grow together on a minimal agar plate, free of amino acids, which would not support the growth of either mutant alone. The nature of this syntrophism forms the s...

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Isoleucine and Valine Metabolism in Escherichia coZi

On the basis of isotopic results obtained with Torulopsis utilis and Neurospora crassa, Strassman et al. (1) and Adelberg (2) have proposed a mechanism for valine biosynthesis in which pyruvate is converted to a-acetolactate. Acetolactate would then undergo a rearrangement to yield the carbon skeleton of valine. Abelson (3) showed that pyruvate, in competition with glucose, gave rise to the car...

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Isoleucine and Valine Metabolism in Escherichia Coli. Xii. Characterization of a Factor Involved in Acetolactate Formation.

Leavitt, Richard I. (Long Island Biological Association, Cold Spring Harbor, N.Y.). Isoleucine and valine metabolism in Escherichia coli. XII. Characterization of a factor involved in acetolactate formation. J. Bacteriol. 88:172-178. 1964.-An unknown factor required for the formation of acetolactate, the first five-carbon precursor of valine, is described. The presence of this factor eliminates...

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Isoleucine and valine metabolism of Escherichia coli. XVI. Pattern of multivalent repression in strain K-12.

The levels of the five enzymes required for isoleucine and valine synthesis were examined under several growth conditions in strain K-12 of Escherichia coli and mutants derived from it. In strains with wild type repressibility, the same pattern of derepression was found on limiting isoleucine as is found to be constitutive in strain Tir-8, which has an altered isoleucine-activating enzyme. Homo...

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ژورنال

عنوان ژورنال: Journal of Bacteriology

سال: 1955

ISSN: 0021-9193,1098-5530

DOI: 10.1128/jb.70.2.241-248.1955